METHYLATED B-COMPLEX

This advanced B-complex formulation includes eight essential B vitamins along with choline, inositol, and biologically active folate as 5-MTHF for optimal methylation. Methylation is a critical biochemical process that converts homocysteine into methionine and cysteine, supporting cardiovascular and nervous system health.*

B vitamins are essential for the body’s ability to convert food into cellular energy. These water-soluble vitamins are absorbed in the small intestine and metabolized in the liver into their active coenzyme forms. Acting as coenzymes in the Krebs cycle, they are vital for the production of adenosine triphosphate (ATP), the body’s primary energy currency. Moreover, B vitamins like folate, B6, and B12 play pivotal roles in methylation, a process crucial for converting homocysteine into methionine and cysteine. Methylation influences DNA repair, gene expression, and overall mental and physical health.*

Thiamine (Vitamin B1)

Thiamine is a key cofactor in A TP production within the Krebs cycle and is required for metabolizing fats, proteins, and carbohydrates. Modern diets often lack sufficient thiamine due to the over-processing of grains. Research from randomized, double-blind, placebo-controlled trials indicates that high-dose thiamine supplementation may also support balanced blood sugar levels.¹*

Riboflavin (Vitamin B2)

Riboflavin serves as a precursor for flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), critical for energy production and antioxidant activity. Riboflavin deficiency can lead to oxidative stress and impaired energy production. Studies suggest that maintaining optimal riboflavin levels can help promote healthy blood pressure, especially in genetically predisposed individuals.²*

Niacin (Vitamin B3)

Niacin, transformed into NAD and NADP in the body, is a cofactor in mitochondrial energy production. It supports oxidation-reduction reactions and promotes cardiovascular health, with substantial evidence demonstrating its role in maintaining healthy cholesterol levels.³*

Vitamin B6

With involvement in over 100 enzymatic reactions, B6 is vital for lipid metabolism, neurotransmitter production, immune function, and hormone regulation. Studies show that higher dietary intake of B6 supports cardiovascular health and enhances lymphocyte activity, promoting immune function in older adults.^4,5*

Folate (5-MTHF)

Folate is indispensable for DNA synthesis, methylation, and mitochondrial energy metabolism. Unlike folic acid, which requires enzymatic conversion, 5-MTHF is bioactive and readily utilized by the body. This ensures better folate absorption, particularly in individuals with suboptimal enzyme activity. Folate also supports neural tube development during pregnancy and overall cellular function.*

Vitamin B12

Essential for fat and carbohydrate metabolism, protein synthesis, and mitochondrial energy regulation, B12 is primarily found in animal-based foods. This nutrient supports neurological health, mood, and energy production. V egan and vegetarian diets often lack adequate B12, making supplementation critical.⁶*

Biotin

Biotin is vital for the metabolism of fats, carbohydrates, and proteins, playing a key role in cellular processes and macromolecule synthesis. It is also associated with promoting healthy hair strength and growth^6,7*

Pantothenic Acid (Vitamin B5)

Pantothenic acid and its active form, CoA, are essential for synthesizing fatty acids, phospholipids, amino acids, and steroid hormones. Approximately 95% of CoA resides in mitochondria, underscoring its role in energy production. Research highlights pantothenic acid’s ability to support tissue repair and regulate blood lipids.^8,9,10*

Choline Bitartrate

Although not a B vitamin, choline is critical for forming cellular membranes and lipoproteins. It also synthesizes acetylcholine, a neurotransmitter vital for brain and muscle function. Choline supports cognitive health and cellular integrity.*

1. Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. Eur J Nutr. 2013 Oct;52(7):1821-4. Epub 2013 May 29.

2. Wilson CP, Ward M, McNulty H, Strain JJ, Trouton TG,Horigan G, Purvis J, Scott JM. Am J Clin Nutr. 2012 Mar;95(3):766-72. Epub 2012 Jan 25.

3. Mason CM, Doneen AL. J Cardiovasc Nurs. 2012 Jul-Aug;27(4):303-16.

4. Rimm EB, Willett WC, Hu FB, et al. JAMA. 1998;279(5):359-364.

5. Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN. Am J Clin Nutr. 1991;53(5):1275-1280.

6. Huskisson E, Maggini S, Ruf M. J Int Med Res. May-Jun 2007;35(3):277-289.

7. Mock DM. Biotin. In: Ziegler E, Filer LJ, eds. Present Knowledge in Nutrition: International Life Sciences Institute; 1996:220-235.

8. Plesofsky-Vig N. Pantothenic Acid. In: Ziegler E, Filer LJ,eds. Present Knowledge in Nutrition: International Life Sciences Institute.; 1996:236-244.

9. Naruta E, Buko V. Exp Toxicol Pathol. 2001 Oct;53(5):393-8.

10. Ellinger S, Stehle P. Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):588-95. Review.