ENHANCE

Enhance is a cutting-edge dietary supplement formulated to support longevity and promote healthy aging. As we age, our cells undergo transformations that impact our well-being and lifespan, including diminished mitochondrial function, reduced autophagy, and decreased cellular renewal. Enhance leverages a precise blend of six key ingredients, including Arginine Alpha-Ketoglutarate (AAKG), Trimethylglycine (TMG), Bergamot Orange Extract, Epigallocatechin Gallate (EGCG), Taxifolin, and Spermidine. These ingredients have demonstrated efficacy in promoting healthspan, optimizing epigenetic aging, and supporting mitochondrial function and autophagy, thus facilitating cellular renewal. By targeting crucial aspects of cellular function such as mitochondrial health, oxidative stress, gene expression, and cellular renewal, Enhance offers a comprehensive approach to support healthy aging and optimize overall cellular well-being, contributing to graceful aging and enhanced longevity.

Arginine Alpha-Ketoglutarate

Arginine Alpha-Ketoglutarate (AAKG) is a vital molecule in the tricarboxylic acid (TCA) cycle, a central pathway for energy production in cells, and is critical in cellular energy metabolism and functions such as DNA and protein synthesis. AAKG acts as a precursor to nitric oxide (NO), a signaling molecule involved in various cellular processes. By supporting nitric oxide production, AAKG promotes blood flow and oxygen delivery to tissues, optimizing mitochondrial function. Furthermore, AAKG exhibits potent antioxidant properties, reducing oxidative stress and preserving mitochondrial integrity. The combined effects of AAKG on nitric oxide production, blood flow, oxygen delivery, and antioxidation contribute to its ability to promote longevity.^1,2

Trimethylglycine

Trimethylglycine (TMG), also known as betaine anhydrous, is a naturally occurring compound with diverse physiological functions. TMG acts as a methyl donor, supporting DNA and histone methylation, which play critical roles in gene expression regulation and maintaining cellular function. By modulating gene expression, TMG helps optimize cellular function and contributes to its longevity-promoting effects.^3,4

Bergamote^®

Natural polyphenols found in fruits, vegetables, and tea exhibit potential in the prevention and treatment of cancer through various mechanisms of action. These include antioxidant activity, modulation of cell signaling pathways, DNA methylation, and apoptosis. Bergamote^® (bergamot orange extract), rich in polyphenols such as flavonoids and citrus bergamia polyphenols (CBPs), offers multiple mechanisms of action that promote longevity. Its potent antioxidant properties neutralize reactive oxygen species (ROS) and reduce oxidative stress. It has been shown to support cardiovascular health and support healthy cholesterol, blood sugar levels and weight loss.^5,6,7 Additionally, bergamot orange extract supports endothelial function, promoting blood flow and cardiovascular health.^8,9

Epigallocatechin Gallate

Epigallocatechin gallate (EGCG), a polyphenol found in green tea, promotes longevity through various mechanisms. EGCG scavenges free radicals, reduces oxidative stress, and protects cellular components as a potent antioxidant. Furthermore, EGCG supports autophagy, a cellular process that clears damaged proteins and organelles, promotes cellular function and support longevity.^10,11

Taxifolin

Bioactive compounds, including polyphenols and flavonoids, possess the ability to support a healthy inflammatory response, including the NF-κB pathway and cytokine production. Taxifolin, also known as dihydroquercetin, is a flavonoid found in various plant sources that exhibits diverse mechanisms of action contributing to its longevity-promoting effects. It acts as a potent antioxidant, effectively scavenging free radicals and reducing oxidative stress, which can lead to cellular damage and aging. Additionally, taxifolin enhances mitochondrial biogenesis and supports electron transport chain activity, resulting in energy production and cellular respiration.^12,13

Spermidine

Spermidine is a polyamine naturally present in various foods and cells. It plays a crucial role in cellular processes such as autophagy and gene expression regulation. Spermidine promotes autophagy, which removes damaged cellular components and supports cellular rejuvenation. By supporting autophagy, spermidine helps maintain cellular health. It also exhibits antioxidant properties, protecting cells from oxidative damage. Furthermore, spermidine regulates gene expression by interacting with chromatin and influencing histone modifications, contributing to cellular homeostasis and longevity.^14,15

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2. Boccardi V, Paolisso G, Mecocci P. Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging (Albany NY). 2016 Jan;8(1):12-5. doi: 10.18632/aging.100886. https://doi.org/10.18632/aging.100886

3. Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. doi: 10.1155/2015/181260. https://doi.org/10.1155%2F2015%2F181260

4. Yao HT, Li CC, Chang CH. Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats. Nutrients. 2019 Aug 10;11(8):1862. doi: 10.3390/nu11081862. https://doi.org/10.3390/nu11081862

5. Ross Walker, Elzbieta Janda and Vincenzo Mollace. The Use of Bergamot-derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action. Cardiac Health and Polyphenols. Chp 84, Pg 1085-1103, 2014. http://dx.doi.org/10.1016/B978-0-12-398456-2.00084-0

6. Micaela Gliozzi, Ross Walker, Elzbjeta Janda, Vincenzo Mollace. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol, LOX-1 expression and Protein Kinase B phosphorylation in patients with hyperlipidemia. International Journal of Cardiology Dec 2013, 170(2):140-5. https://doi.org/10.1016/j.ijcard.2013.08.125

7. Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia 82 (2011) 309–316. https://doi.org/10.1016/j.fitote.2010.10.014

8. Liu P, Huang J, Mei W, Zeng X, Wang C, Wen C, Xu J. Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression. Bioengineered. 2021 Dec;12(2):9496-9506. doi: 10.1080/21655979.2021.1996018. https://doi.org/10.1080%2F21655979.2021.1996018

9. Saini RK, Ranjit A, Sharma K, Prasad P, Shang X, Gowda KGM, Keum YS. Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants (Basel). 2022 Jan 26;11(2):239. doi: 10.3390/antiox11020239. https://doi.org/10.3390%2Fantiox11020239

10. Inoue, T., Saito, S., Tanaka, M., Yamakage, H., Kusakabe, T., Shimatsu, A., Ihara, M., & Satoh-Asahara, N. (2019). Pleiotropic neuroprotective effects of Taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences, 116(20), 10031–10038. https://doi.org/10.1073/pnas.1901659116

11. Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85. https://doi.org/10.2174/187152810793358741

12. Emile Andriambeloson and others, Natural Dietary Polyphenolic Compounds Cause Endothelium-Dependent Vasorelaxation in Rat Thoracic Aorta, The Journal of Nutrition, Volume 128, Issue 12, December 1998, Pages 2324–2333, https://doi.org/10.1093/jn/128.12.2324

13. Li J, Sun M, Cui X, Li C. Protective Effects of Flavonoids against Alzheimer's Disease: Pathological Hypothesis, Potential Targets, and Structure-Activity Relationship. Int J Mol Sci. 2022 Sep 2;23(17):10020. https://doi.org/10.3390%2Fijms231710020

14. Madeo F, Zimmermann A, Maiuri MC, Kroemer G. Essential role for autophagy in life span extension. J Clin Invest. 2015 Jan;125(1):85-93. https://doi.org/10.1172%2FJCI73946

15. Eisenberg, T., Knauer, H., Schauer, A. et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305–1314 (2009). https://doi.org/10.1038/ncb1975