Immune Shield

Immune Shield ExactPax^TM is designed to support optimal immune function through complementary and synergistic pathways. This customized packet contains Defend Pro, Enhance and Gl Prime. Defend Pro lays the antioxidant foundation by modulating immune cell activity and antimicrobial responses.^1-4 Enhance supports mitochondrial function to fuel immune cells and facilitate autophagy-mediated recycling of cellular components.^5-7 GI Prime reinforces intestinal defenses by nurturing the microbiome, promoting barrier integrity. and balancing mucosal immunity.^8-11 This multi-pronged approach fortifies the bodys resistance and immune system resilience at the cellular, mitochondrial, and gut levels.

Defend Pro 

Defend Pro combines vitamins A, D, K, and E with the clinically-studied bioavailability enhancer AstraGin^®. Vitamin A supports the function of neutrophils, macrophages, and natural killer cells¹. Vitamin D modulates antimicrobial proteins and cytokine production². Vitamin K2 regulates inflammatory processes and immune cell survival³. Vitamin E fortifies antioxidant defenses against oxidative stress.⁴ Absorption and bioavailability is enhanced for all of these nutrients via AstraGin^®, which also provides prebiotic support for gut health.⁵

• Supports immune function
• Supports effective calcium deposition
• Supports cardiometabolic function
• Supports optimal hormone metabolism 

Gl Prime

GI Prime combines postbiotic IMMUSE™, the immune-balancing nutrient Epicor^®, butyrate-producing Butyragen™, and targeted spore probiotics. IMMUSE™ supports mucosal immunity by promoting tight junction integrity and balanced cytokine secretion⁹. EpiCor^® modulates immune responses by stimulating anti-inflammatory cytokine production¹⁰. Butyrate™ serves as the primary energy source for colonocytes and aids microbial cross-feeding¹¹. The hardy spores help maintain microbiome diversity and pathogen resistance¹².

• Support for digestive dysregulation
• Assistance with gut dysbiosis
• Acute & ongoing immune system support
• Gut permeability protocols 

Enhance

Enhance works on a different part of the immune system, which is commonly overlooked: the mitochondria. Enhance targets mitochondrial function and immune resilience with the novel nutrient Spermidine, Arginine Alpha-Ketoglutarate (AAKG), Trimethylglycine (TMG), Bergamot Orange Extract, Epigallocatechin Gallate (EGCG), and Taxifolin. Mitochondria are essential for meeting the energy demands of immune cells during an immune response, providing the ATP required for functions like cellular migration, cytokine production, and proliferation. Additionally, mitochondria play a key role in microbe specific immunity through their involvement in interferon and inflammasome signaling pathways. The taxifolin, EGCG and bergamot extract provide key antioxidant support. Spermidine activates autophagy to remove damaged mitochondria and misfolded proteins, recycling cellular components⁶. TMG optimizes methylation for cellular energy production via proper mitochondrial metabolism⁷. AKG is a key intermediate in the Krebs cycle, fueling mitochondria to meet the energy demands of immune cells⁸.

• Supports stamina and endurance
• Promotion of Nft2 antioxidant pathways
• Promotes longevity through cellular renewal and autophagy
• Maintains healthy lipid and blood sugar metabolism

1. Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018 Sep 6;7 (9):258.
   
   
2. Sassi F, Tamone C, D'Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018 Nov 3;10(11):1656.
   
   
3. Maresz K. Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular. Integr Med (Encinitas). 2021 Aug;20(4):34-38.
   
   
4. Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life. 2019 Apr;71(4):487-494.
   
   
5. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Kearney J, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Engel KH, Frenzel T, Heinonen M, Marchelli R, Neuhäuser-Berthold M, Poulsen M, Schlatter JR, van Loveren H, Acker/ R, Knutsen HK. Safety of a botanical extract derived from Panax notoginseng and Astragalus membranaceus (AstraGin™') as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2020 May 13;18(5):e06099
   
   
6. Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019 Jan; 15 (1):165-168.
   
   
7. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients. 2013 Sep 9;5(9):3481-95.
   
   
8. Liu S, Yang J, Wu Z. The Regulatory Role of a-Ketoglutarate Metabolism in Macrophages. Mediators Inflamm. 2021 Mar 29;2021:5577577.
   
   
9. Liang B, Xing D. The Current and Future Perspectives of Postbiotics. Probiotics Antimicrob Proteins. 2023 Dec;15(6):1626-1643.
   
   
10. Moyad, M. A., et al. Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs 2008, 28 (1), 50-5.
    
    
11. Bruins MJ, Van Dael P, Eggersdorfer M. The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging. Nutrients. 2019 Jan 4;11(1):8
    
    
12. Rybak , Haas KN, Dhaliwal SK, Burney WA, Pourang A, Sandhu SS, Maloh J, Newman JW, Crawford R, Sivamani RK. Prospective Placebo-Controlled Assessment of Spore-Based Probiotic Supplementation on Sebum Production, Skin Barrier Function, and Acne. J Clin Med. 2023 Jan 23;12(3):895.