CARDIO PRIME+

Cardiovascular and metabolic health are multi-faceted systems that require a holistic approach to provide authentic, effective support. More often than not, two overlooked areas are (1) energy production and (2) glucose metabolism. The connection between heart health and these two additional factors is very well established and the data continues confirming as much. So with these essential elements layered on top of more ‘tried and true’ ingredients that research has long supported as being vital to cardiovascular health, InfiniWell carefully and meticulously put together this ‘all-in-one’, evidence-based cardiometabolic formula, called Cardio Prime+. Cardio Prime+ represents the latest nutritional innovation to provide a multi-faceted approach to cardiometabolic health.

NAD3^®

The first, and perhaps most cutting-edge inclusion, is the NAD3® . This is a multi patents-pending nutraceutical containing a unique Wasabi japonica extract, Theacrine, and Copper(I)-Niacin complex. Preliminary pre-clinical and human studies, in collaboration with the DNA methylation and epigenetic experts at TruDiagnostic and the multi-omics Molecular and Applied Sciences Laboratory at Auburn University, suggest the mechanism by which this trio works is by supporting enzymes that facilitate the conversion of NAD+ precursors, such as Niacin, Niacinamide, Nicotinamide Riboside (NR) and/or NMN to NAD+, while also regulating the overactivity of proteins that deplete & consume NAD+. Collectively, these data support the use of NAD3® in combination with any NAD+ precursor for facilitating net cellular NAD+ status.

NSK-SD^® Nattokinase

NSK-SD^® Nattokinase - The second ingredient is a proteolytic enzyme, which operates very differently from a digestive enzyme in the body. Proteolytic enzymes work systemically, outside the confines of the digestive system, and interact specifically with fibrin to support healthy levels of accumulation. NSK-SD^® , is a patented, branded, uniquely produced, and extensively studied enzyme. NSK-SD^® is isolated from natto, a food made from fermented soybeans.

This enzyme has demonstrated, quite consistently, its ability to positively impact cardiovascular health. Clinical research showing the physiological and biochemical benefits of NSK-SD^® highlighted in over 30+ published studies in the areas of supporting healthy blood pressure, providing critical fibrinolytic activity and supporting healthy levels of platelet and red blood cell aggregation as well as optimal blood viscosity.^2,3

Bergamot

Citrus bergamia, known as Bergamot, a fragrant fruit the size of an orange with a yellow color similar to a lemon is included in this formulation. It’s been clinically shown to support heart health by promoting healthy cholesterol, blood sugar, and triglyceride levels and supporting blood vessel function.³ 

CurcuPrime^® (Tetrahydrocurcumin)

CurcuPrime^® Curcumin is an essential piece of the metabolic and cardiovascular puzzle. While there are often variations in the active percentage of curcumin, Cardio Prime+ features Tetrahydrocurcumin (4HC). This is a partially reduced derivative of curcumin so it is NOT found in turmeric. However, it is one of, if not the, most potent metabolite of curcumin. 4HC is also known for being more stable than curcumin because it has superior absorption and bioavailability properties. Tetrahydrocurcumin is well known for its anti-oxidative and cytoprotective activities. Its ability to reach target tissue and be stored for later use has also been a mechanism that has been identified. In fact, it was found that even without the presence of curcumin, tetrahydrocurcumin is stored in adipose tissue for four weeks after ingestion.⁴

Tetrahydrocurcumin has many more desirable biological and pharmacological properties than curcumin. Beyond the fact that 4HC has demonstrated a prolonged plasma half-life when compared to standard curcumin, it has been recognized as a potent antioxidant that supports a series of metabolic and overall health benefits including supporting healthy blood sugar and insulin levels, healthy HDL and triglyceride levels, supporting the structure and function of hepatic cells and supporting healthy blood pressure levels.⁴

VasoDrive-AP^®

VasoDrive-AP^® (AmealPeptide) - Rounding out this formulation and staying true to our peptide roots, we’ve included a tripeptide in Cardio Prime+. The role of peptides in cardiometabolic health is well documented and V asoDrive-AP^®, derived from casein (milk protein), and consisting of two lactotripeptides - V aline-Proline-Proline (VPP) and Isoleucine-Proline-Proline (IPP) (both of which have been shown to help optimize blood vessel constriction, which in turn, aids with blood flow) represents one of the most innovative peptides available..

1. Sumi H, Hamada H, Nakanishi K, et al. Acta Haematol 1990;84:139-43. DOI: 10.1159/000205051Sumi

2. Ross Walker, Elzbieta Janda and Vincenzo Mollace. Cardiac Health and Polyphenols. Chp 84, Pg 1085-1103, 2014. http://dx.doi.org/10.1016/B978-0-12-398456-2.00084-0

3. Micaela Gliozzi, Ross Walker, Elzbjeta Janda, Vincenzo Mollace. International Journal of Cardiology Dec 2013, 170(2):140-5. https://doi.org/10.1016/j.ijcard.2013.08.125

4. ZX, Su ZR. Curcumin's Metabolites, Front Pharmacol. 2018 Oct 17;9:1181. https://doi:10.3389/fphar.2018.01181.