BPC Probiotic | ABC

ABC (Akkermansia-BPC-Complex) provides a new approach to cellular longevity via gut health and metabolic optimization. Informed by the latest research on microbiome profiles in Centenarians. This "first-of-it's-kind" formulation is at the cutting edge of longevity science. Two primary areas emerge from the data as being critical for longevity: gut barrier integrity and metabolic function, especially as it relates to GLP-1. ABC is designed specifically to harness the synergistic power of Akkermansia, BPC, and Sunfiber® to support metabolic optimization and microbiome profiles found amongst blue zone Centenarians.

AKKERMANSIA & BPC BASICS 

First, it is important to understand the biochemical role Akkermansia muciniphila plays in the gut as it relates to metabolic health. It all comes down to its interactions with glucagon-like amino-1 (GLP-1), an important hormone produced by the intestinal cells, which plays a vital role in regulating glucose metabolism and insulin secretion. Akkermansia muciniphila is known to facilitate the natural production and secretion of GLP-1 in the intestine by utilizing mucin, a glycoprotein present in the mucus lining of the gut. as its primary source of energy.1 During the process of mucin degradation, Akkermansia releases metabolites that stimulate the intestinal L-cells to secrete more GLP-1.2 The increased levels of GLP-1 then act on various tissues, such as the pancreas, liver, and muscles, to promote glucose metabolism, support insulin sensitivity, and regulate appetite. ultimately contributing to overall metabolic health.3

BPC, on the other hand, plays an important supporting role via its effects on gut tissue and barrier integrity. This amino is responsible for maintaining and continuously supporting the intestinal architecture. which allows the myriad of chemical interactions to occur without interruption within the gut ecosystem.

BPC / AKKERMANSIA SYNERGY 

Because the biochemical relationship between Akkermansia and the intestinal barrier is heavily dependent on a high level of structural integrity within the gut lining, BPC serves as the ideal companion. As BPC plays a vital role in rejuvenating and maintaining gut tissues, supporting barrier function, it creates the optimaI environment for Akkermansia's broad biochemical function.

Additionally, Sunfiber serves as a rich prebiotic source for short-chain fatty acid production, in particular butyrate. As a trio, they all work in harmony to support a healthy gut microbiome, improve nutrient absorption and optimize metabolic function. This synergistic interaction lays the foundation for longevity by fostering a resilient gut environment that contributes to overall healthspan and vitality.

1. Derrien, M. et al. (2004). Bulletin of the IDF, 388, pp.107-112.

2. Plovier. H. et al. (2017). Nature Medicine, 23(1), pp.107-113.

3. Baothman OA, Zamzami MA, Ta her I, Abu baker J, Abu-Farha M. Lipids Health Dis. 2016 Jun 18;15:108.

4. Rodrigues VF, Elias-Oliveira J, Pereira fs. Pereira JA, Barbosa SC, Machado MSG, Carlos D. Front lmmunol. 2022 Jul 7;13:934695.

5. Depommier C., Everard A., Druart C .. Plovier H .. V an Hui M .. Vieira-Silva S., Falony G .. Raes J., Maiter D., Delzenne N.M .. et al. Nat. Med. 2019;25:1096-1103.

6. Wang z. Cui S, Zhang T, Wang W, Li J, Chen YQ. Zhu SI. mSystems. 2023 Oct 26;8(5):e0057323.

7. Everard A., Belzer C .. Geurts L. Ouwerkerk J.P .. Druart C .. Bindels LB., Guiot Y .. Derrien M .. Muccioli G.G .. Delzenne N.M .. et al. Proc. Natl. Acad. Sci. USA. 2013;110:9066-9071.

8. Deng L. Ou z .. Huang D .. Li C., Luz .. Liu w .. Wu F .. Nong C .. Gao J .. Peng Y . Microb. Pathog. 2020;147:104353.

9. Ai X. Liu Y . Shi J, Xie X, Li L, Duan R. Lv Y , Xiong K. Miao Y , Zhang Y . Appl Microbial Biotechnol. 2024 Apr 15;108(1):300.