CALMA

Calm serves as a catalyst for relaxation, cognitive amplification, and holistic well-being. Its formulation encompasses an unparalleled blend of three ingredients: L-TeaActive^®, BaCognize^®, and DHH-B (Dihydrohonokiol), each boasting distinctive properties that harmoniously coalesce to foster relaxation, heighten cognitive prowess, and aid neurotransmitter modulation, neuroprotection, and stress response regulation. Within the confines of each meticulously curated ingredient lies a key to unlock untapped potential and bask in the zenith of tranquility; a testament to the human mind.

L-TeaActive^®

L-TeaActive^®, extracted from the leaves of Camellia sinensis, stands as a testament to the potential of L-theanine, a non-protein amino acid revered for its many profound abilities. By instigating the production of alpha brain waves, L-TeaActive^® manifests a serene mental state and unwavering focus. Additionally, this remarkable supplement also refines mental alertness and attention span, rendering it invaluable for those seeking to optimize their cognitive capabilities. Finally, and perhaps most notably, the influence exerted by L-TeaActive^® on neurotransmitter activity contributes to a positive mood and an overarching sense of well-being. This direct support for inhibitory neurotransmitters facilitates the attainment of restorative sleep, engendering mornings marked by vigor and vitality.^1,2

BaCognize^®

BaCognize^®, derived from the venerable Bacopa monnieri, heralds a new era of cognitive empowerment. This botanical extract unfurls an assortment of cognitive-enhancing attributes, including memory augmentation, mental acuity, attentiveness, and stress mitigation. By modulating neurotransmitters, such as acetylcholine, serotonin, and dopamine that are pivotal to memory, attention, mood regulation, and overall cognitive function, BaCognize^® unfurls a tapestry of cognitive revitalization.³ Its antioxidant activity safeguards neuronal cells from the ravages of oxidative stress. Moreover, BaCognize^® nurtures neuronal resilience, emboldening the endurance of these vital brain cells. Facilitating synaptic plasticity, BaCognize^® fosters efficient neural communication, endowing individuals with the dexterity to navigate the intricacies of thought. Furthermore, its proclivity to promote neurogenesis in regions intertwined with memory and learning bears testament to its multifaceted cognitive support. Notably, BaCognize^® tempers the deleterious impact of stress on cognitive function by modulating the stress response system, thus fostering a haven of tranquility.⁴

DHH-B

Dihydrohonokiol (DHHB), derived from the revered Magnolia officinalis, embarks on a noble endeavor to embrace tranquility. Its sublime properties offer a vista of relaxation, cognitive support, and cellular harmony. By assuaging the stressors of life, DHH-B ushers individuals into a realm of serenity and tranquility, lifting the burdens of their minds. Additionally, DHH-B extends its benevolent touch to cognitive realms, supporting optimal brain function and fortifying cognitive prowess. As a vigilant free radical scavenger, it stands as a stalwart guardian, protecting cells from the perils of oxidative damage and nurturing cellular well-being.

By enhancing GABAergic activity and deftly engaging GABA receptors in the brain, Dihydrohonokiol orchestrates calmness and tranquility.⁵ Moreover, Dihydrohonokiol exhibits neuroprotective effects, safeguarding neurons from oxidative stress in the brains most delicate tissues.^6,7

1. White DJ, de Klerk S, et al. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo Controlled, Crossover Trial. Nutrients. 2016;8(1):53. doi:10.3390/nu8010053.

2. Higashiyama A, Htay HH, et al., Effects of L-theanine on attention and reaction time response, Journal of Functional Foods. 2011; doi:10.1016/j.j.2011.03.009. 

3. Lopresti, A. L., Smith, S. J., Ali, S., Metse, A. P., Kalns, J., & Drummond, P. D. (2021). Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods, 85, 104671. ISSN 1756-4646. https://doi.org/10.1016/j.jff.2021.104671.

4. Best T, Clarke C, Nuzum N, Teo WP. Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study. Nutr Neurosci. 2021 Nov;24(11):873-884. doi: 10.1080/1028415X.2019.1690288. Epub 2019 Nov 18. PMID: 31736428.https://doi.org/10.1080/1028415x.2019.1690288.

5. Maruyama Y, Kuribara H, Kishi E, Weintraub ST, Ito Y. Confirmation of the anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments. J Pharm Pharmacol. 2001 May;53(5):721-5. doi: 10.1211/0022357011775848. PMID: 11370711. https://doi.org/10.1211/0022357011775848

6. Kuribara H, Kishi E, Kimura M, Weintraub ST, Maruyama Y. Comparative assessment of the anxiolytic-like activities of honokiol and derivatives. Pharmacol Biochem Behav. 2000 Nov;67(3):597-601. doi: 10.1016/s0091-3057(00)00401-9. PMID: 11164091. https://doi.org/10.1016/s0091-3057(00)00401-9

7. Woodbury, A., Yu, S. P., Wei, L., & Garcia, P. (2013). Neuro-Modulating Effects of Honokiol: A Review. Frontiers in Neurology, 4, 130. https://doi.org/10.3389/fneur.2013.00130