GHK-Cu acts directly on fibroblasts by increasing production of mRNA and protein for collagen, elastin, proteoglycans, glycosaminoglycans, and decorin; all of which are critical components in tissue repair and maintenance. Further, it acts to stimulate the production of metalloproteases and protease inhibitors which function to remove damaged tissue proteins. Together these functions increase the function of the cellular machinery and scaffolding to initiate repair and healthier tissue.