Cardiovascular and metabolic health are multi-faceted systems that require a holistic approach in order to provide authentic, effective support. More often than not, two areas that are overlooked are 1. energy production and 2. glucose metabolism. The connection between heart health and these two additional factors is very well established and the data continues confirming as much. So with these undeniably important elements layered on top of more ‘tried and true’ ingredients that research has long supported as being essential to cardiovascular health, InfiniWell carefully and meticulously put together this ‘all-in-one’, evidence based cardiometabolic formula, called Cardio Prime+. Cardio Prime+ represents the latest in nutritional innovation aimed at providing the multi-faceted approach to cardiometabolic health.
Before delving into the ingredients and how this formula works, it’s important to realize who the demographic is that should be paying attention to their cardiovascular and cardiometabolic systems. Most functional medicine doctors will say that anyone with a family history of heart disease should look at taking cardio-supportive supplements. But practically speaking, there is much evidence to suggest that anyone, male or female (cardiovascular issues have long been relegated predominately to men but in recent decades that has shifted to also include women) living in today’s harsh environment, which produces excessive amounts of oxidative stress through diet and lifestyle choices impacting foundational systems, including the cardiometabolic system, should include supplementation into their care plan in order to offset the deleterious nature of our surroundings. And considering that despite all of the advances in medicine that cardiovascular disease and metabolic issues such as diabetes still reside at the top of the list of most deadly diseases, that makes a great deal of sense. Perhaps if we approach the heart and metabolism as systems to be regularly and consistently nourished rather than waiting for some level of dysfunction and then responding reactively, we could see meaningful changes in healthcare and perhaps Cardio Prime+ is a step in that direction.
The first, and perhaps most cutting edge inclusion, is the NAD3. This is a multi patents-pending nutraceutical containing a unique Wasabi japonica extract, Theacrine and Copper(I)-Niacin complex. Preliminary pre-clinical and human studies, in collaboration with the DNA methylation and epigenetic experts at TruDiagnostic and the multi-omics Molecular and Applied Sciences Laboratory at Auburn University, suggest the mechanism by which this trio works is by upregulating enzymes that facilitate the conversion of NAD+ precursors, such as Niacin, Niacinamide, Nicotinamide Riboside (NR) and/or NMN to NAD+, while also suppressing the activity of proteins that deplete & consume NAD+. Collectively, these data support the use of NAD3® in combination with any NAD+ precursor or “booster” (as an ideal companion) for supporting net cellular NAD+ status.
In vitro AND in vivo human clinical data from the recently completed 'ENHANCE Trial' of NAD3® supports the hypothesis that cellular NAD+ concentration alone is not the linchpin to longevity. Rather, there appears to be a “leaky sink” whereby NAD+ levels decrease as a result of chronic inflammation and aberrant immune activation. NAD+ depletion could be limited by controlling systemic inflammation and keeping NAD+ salvage pathways active. Thus, one strategy to enhance longevity appears to be providing sufficient NAD precursor for salvage pathways, plus activating the downstream stress resilience and pro-longevity gene networks (e.g., SIRT3/6, SOD3, TERF1/POT1, CCL3, CXCL9, PGC1-A, SOX2/KLF4, etc.). Moreover, human data with oral supplementation of NAD3® for 12 weeks demonstrated the ability to support various independent cardiovascular risk factors such as VLDL, TAGs, LDL-C and Total Cholesterol. In the same study, beneficial changes in intracellular NAD+ levels were noted, despite the fact that NAD3® does NOT contain an appreciable dose of NAD/B3 vitamin precursor. Taken together the pre-clinical, mechanistic data on NAD3 (and its constituents, theacrine, long-chain allyl and phenethyl ITC-rich Wasabi extract) and first-in-human ENHANCE Trial data provide a strong basis for NAD3 as part of a comprehensive plan to optimize cardiometabolic health and longevity.
The second ingredient is a proteolytic enzyme, which operates very differently from a digestive enzyme in the body. Proteolytic enzymes work systemically, outside the confines of the digestive system and protect against excessive fibrin formation and accumulation (fibrin being converted from fibrinogen, which can be triggered by excessive amounts of inflammation among other things and at high levels can wreak havoc on the cardiovascular system via excessive clotting of blood). This enzyme, NSK-SD, is a patented, branded, uniquely produced and extensively studied enzyme. NSK-SD is isolated from natto, a food made from fermented soybeans.
This enzyme has demonstrated, quite consistently, its ability to positively impact cardiovascular health. Clinical research showing the physiological and biochemical benefits of NSK-SD highlighted in over 30+ published studies in the areas of supporting healthy blood pressure, providing key fibrinolytic activity so as to mitigate excessive blood clotting while not inhibiting wound healing, supporting healthy levels of platelet and red blood cell aggregation as well as blood viscosity, hsCRP levels throughout the body and blood flow.
And what would a cardiometabolic formula be without some form of curcumin? Curcumin is an essential piece to the metabolic and CV puzzle. In fact, while there are often variations in terms of the active percentage of curcumin, Cardio Prime+ features Tetrahydrocurcumin (4HC). Obviously, this active compound is found, like standard curcumin, in turmeric, however, is a constituent that possesses more potent than normal biological activity. 4HC is known for being more stable than curcumin because it has superior absorption and bioavailability properties. Tetrahydrocurcumin is of special interest because it displays better bioavailability and different biological activity and molecular mechanisms than curcumin. Tetrahydrocurcumin is well known for its anti-oxidative and cytoprotective activities. Its ability to reach target tissue and be stored for later use has also been a mechanism that has been identified. In fact, it was found that even without the presence of curcumin, tetrahydrocurcumin is stored in adipose tissue for four weeks after ingestion.
Tetrahydrocurcumin has many more desirable biological and pharmacological properties than curcumin on its own. Beyond that fact that 4HC has demonstrated a prolonged plasma half life when compared to standard curcumin, it has been recognized as a superior antioxidant that supports a series of metabolic and overall health benefits including supporting healthy blood sugar and insulin levels and supporting healthy LDL and triglyceride, inhibition of lipid peroxidation, supporting the structure and function of hepatic cells and supporting healthy blood pressure levels.
Then we have Citrus bergamia, known as Bergamot, a fragrant fruit the size of an orange with a yellow color similar to a lemon is included in this formulation. It’s been clinically shown to support heart health by promoting healthy cholesterol, blood sugar and triglyceride levels and supporting blood vessel function.
One novel mechanism by which Bergamot works is through its ability to activate AMPK. In terms of blood sugar, and incidentally insulin levels, this is typically seen as the primary mechanism. Its activation of AMPK combined with the structural similarities to other HMG Co-A reductase inhibitors, has led to the theorized mechanism by which Bergamot can support healthy levels of cholesterol production.
Rounding out this formulation and staying true to our peptide roots, we’ve included a tripeptide in Cardio Prime+. The role of peptides in cardiometabolic health is well documented and VasoDriveAP®, derived from casein (milk protein), and consisting of two lactotripeptides -- Valine-Proline-Proline (VPP) and Isoleucine-Proline-Proline (IPP) (both of which have been shown to help optimize blood vessel constriction, which in turn, aids with blood flow) represents the one of the most innovative peptides available.
Relative to the heart, VasoDrive AP® demonstrates an inhibitory activity with regard to angiotensin converting enzyme(ACE) thereby supporting healthy blood pressure levels and by facilitating the endothelial production of nitric oxide (NO), which has a multitude of effects throughout the body.