NMN

NMN is an innovative and cutting-edge supplement designed to support healthy aging and optimize cellular function. This unique product combines the power of Nicotinamide Mononucleotide (NMN), resveratrol, and pterostilbene to provide a synergistic blend of ingredients that target multiple aspects of the aging process. NMN serves as a precursor to NAD+, a vital coenzyme involved in energy metabolism and DNA repair, while resveratrol and pterostilbene activate key longevity pathways. Together, these compounds work in harmony to enhance cellular energy production, combat age-related decline, promote metabolic health, and support cognitive function. NMN offers a comprehensive approach to unlocking the potential of healthy aging, allowing individuals to optimize their vitality and well-being.

Nicotinamide Mononucleotide (NMN) is derived from ribose and nicotinamide (vitamin B3) and acts as a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a coenzyme involved in diverse cellular processes, including energy metabolism and DNA repair. NMN serves a crucial role in supporting cellular energy production by promoting NAD+ synthesis, thereby enhancing mitochondrial function and facilitating ATP production.

One of the most intriguing aspects of NMN lies in its potential as an anti-aging and longevity agent. Studies have focused on its ability to improve mitochondrial function, enhance DNA repair mechanisms, and combat age-related decline. Promising results from animal studies have shown improved health span and increased lifespan following NMN supplementation. Another area where NMN demonstrates promise is in metabolic health by supporting glucose metabolism, insulin sensitivity and promoting effective lipid metabolism.¹ Furthermore, NMN may have implications for cognitive function. NMN's ability to support mitochondrial function and cellular repair mechanisms may contribute to the preservation of brain health.²

Resveratrol and pterostilbene are two potent polyphenols renowned for their exceptional anti-aging benefits. Resveratrol, found in grapes, red wine, and berries, has captured significant interest due to its potential to extend lifespan and improve healthspan. It activates SIRT1, a protein associated with longevity, which in turn regulates various cellular processes critical for overall cellular health. Resveratrol mimics the effects of calorie restriction, a dietary intervention known for its longevity- promoting effects. By activating similar pathways involved in energy metabolism and cellular stress response, resveratrol may offer anti-aging benefits. Additionally, resveratrol supports mitochondrial function, the energy-producing centers of cells, thereby promoting cellular vitality. Its potent antioxidant support the body during oxidative stress, contributing to cellular health.³ 

Pterostilbene, structurally similar to resveratrol and found in blueberries, grapes, and other plants, shares many anti-aging properties with its counterpart. It activates SIRT1, which regulates key cellular processes associated with longevity. Pterostilbene, like resveratrol, exhibits robust antioxidant and anti-inflammatory effects, shielding cells from oxidative stress and inflammation, which are implicated in aging and age-related diseases. Pterostilbene has been investigated for its cardiovascular benefits, potentially supporting healthy cholesterol levels, blood vessel health, and overall cardiovascular function. Furthermore, it shows promise in maintaining cognitive function and contributes to brain health and may support memory.⁴

Resveratrol and pterostilbene present a dynamic duo in the realm of anti-aging and cellular health. Their activation of SIRT1, combined with their antioxidant properties, impact on mitochondrial function, and potential cardiovascular and cognitive benefits, position them as valuable compounds in the quest for healthy aging and longevity.

1. Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. https://https://doi: 10.1007/s11357-022-00705-1.

2. Mills KF, Yoshida S, Stein LR, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016;24(6):795–806. https://https://https://doi.org/10.1016/j.cmet.2016.09.013.

3. Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun. 2010 Apr 12;1:3. doi: 10.1038/ncomms1001. PMID: 20975665; PMCID: PMC3641391.

4. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022 Sep 25;27(19):6316. doi: 10.3390/molecules27196316. PMID: 36234852; PMCID: PMC9571692.