GLYNAC

In the ever-evolving world of healthcare, the pursuit of innovative solutions that optimize health and well-being never ceases. GlyNAC, a groundbreaking dietary supplement, utilizes the synergistic power of Glycine and NAC (N-Acetylcysteine) to promote a broad spectrum of longevity support. This includes enhanced antioxidant capacity, detoxification and glutathione synthesis to name a few. GlyNAC serves as a game-changer in aging and is backed by compelling research.

Healthcare professionals know the importance of a strong antioxidant defense system. Glycine, an essential amino acid, plays a pivotal role in fortifying this defense mechanism. It accomplishes this through its involvement in the synthesis of glutathione, often hailed as the body's master antioxidant. This potent compound safeguards our cells against the pernicious effects of oxidative stress, which is implicated in the aging process and various chronic diseases. Glycine plays many parts in the body's intricate biochemical processes:

Detoxification 

Glycine stands as a critical player in phase II detoxification reactions. It aids in the removal of harmful substances such as heavy metals and toxins, contributing to our overall well-being.^1,2,3

Neurotransmitter Regulation 

Glycine works as an inhibitory neurotransmitter in the central nervous system. This balancing offers immense potential in aiding relaxation, managing stress, and supporting cognitive function.³

Collagen Production

Glycine is ally to those passionate about skin health and joint function. It forms the backbone of collagen, the structural protein that keeps our skin supple and our joints in motion.³

N-Acetylcysteine (NAC), a powerful antioxidant and a precursor to glutathione, plays a pivotal role in safeguarding cellular health:

Glutathione Synthesis

NAC takes the stage as a key player in the synthesis of glutathione by enhancing the body's ability to combat free radicals and reduce oxidative stress, creating a fortress of protection within our cells.⁴

Mucus Management

NAC exhibits mucolytic properties, making it a valuable asset for those dealing with respiratory issues. It breaks down and thins mucus, providing much-needed relief for conditions like chronic bronchitis and cystic fibrosis.⁵

Liver Shield

When it comes to liver health, NAC is a reliable companion. It aids the liver in its detoxification processes and shields liver cells from the harmful effects of toxins and medications.⁶

Mental Well-Being

Research has unveiled NAC's potential to positively impact mental health by supporting mood, temperament and overall emotional wellbeing, specifically by targeting glutamate levels in the brain.⁷

1. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022 Mar 7;14(5):1114. doi: 10.3390/nu14051114. PMID: 35268089; PMCID: PMC8912885.

2. Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021 Mar;11(3):e372. doi: 10.1002/ctm2.372. PMID: 33783984; PMCID: PMC8002905.

3. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. Erratum in: Oxid Med Cell Longev. 2022 Feb 23;2022:9857645. PMID: 28337245; PMCID: PMC5350494.

4. Nguyen D, Hsu JW, Jahoor F, Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab. 2014 Jan;99(1):169-77. doi: 10.1210/jc.2013-2376. Epub 2013 Dec 20. PMID: 24081740; PMCID: PMC3879663. 

5. Ozdemir ZC, Koc A, Aycicek A, Kocyigit A. N-Acetylcysteine supplementation reduces oxidative stress and DNA damage in children with β-thalassemia. Hemoglobin. 2014;38(5):359-64. doi: 10.3109/03630269.2014.951890. Epub 2014 Sep 15. PMID: 25222041.

6. Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, Kiani J, Zaare M, Najafipoor F. N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease. Hepat Mon. 2010 Winter;10(1):12-6. Epub 2010 Mar 1. PMID: 22308119; PMCID: PMC3270338.

7. Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011 Mar;36(2):78-86. doi: 10.1503/jpn.100057. PMID: 21118657; PMCID: PMC3044191.