THYROID SUPPORT

Discover the power of Thyroid Support, a cutting-edge nutritional supplement meticulously formulated to promote optimal thyroid function and support overall thyroid health. It has indications spanning from basic and subclinical applications to even the most complex cases of hypothyroidism. Thyroid Support is a synergistic blend of selenium, iodine, vitamin K2, guggulsterone, diiodo-L-thyronine (T2), hydroxytyrosol acetate, and theobromine. This scientifically-backed supplement addresses the entire hypothalamus-pituitary-thyroid axis, boosts energy production, enhances metabolic rate, activates mitochondrial function, and supports overall thyroid metabolism. Thyroid Support is key to unlocking the full potential of thyroid functionality and metabolism to achieve a balanced, energized, and vibrant life.

Selenium as L-Selenomethionine

Selenium, an essential trace mineral, is vital in thyroid hormone synthesis and metabolism. It acts as a cofactor for enzymes involved in the conversion of thyroxine (T4) to its active form, triiodothyronine (T3).¹ Selenium also exhibits antioxidant properties, protecting the thyroid gland from oxidative damage.²

Selenium enhances the activity of selenoproteins, particularly glutathione peroxidases, which help neutralize reactive oxygen species (ROS) and maintain optimal thyroid function.³ It also contributes to regulating thyroid hormone levels by modulating the expression of genes involved in hormone synthesis.⁴

Selenium supplementation improves thyroid function by reducing thyrotropin (TSH) levels and improving thyroxine (T4) to triiodothyronine (T3) conversion.⁵ These findings underscore the importance of selenium in supporting thyroid health.

Iodine from Potassium Iodide

Iodine is an essential mineral required for the synthesis of thyroid hormones. It is a key component of thyroxine (T4) and triiodothyronine (T3), which regulate metabolism, growth, and development.⁶ Iodine is actively transported into thyroid follicular cells, combining with the amino acid tyrosine to form T4 and T3.⁷

These hormones are then released into circulation and affect various target tissues. Iodine deficiency is a well-known cause of thyroid disorders, and supplementation with iodine has been effective in correcting deficiencies and improving thyroid function.⁸ However, it is important to maintain proper iodine balance, as excessive intake can also have adverse effects on thyroid health.

Vitamin K2 as Menaquinone-7

Vitamin K2, specifically Menaquinone-7 (MK-7), is a remarkable nutrient that supports optimal thyroid function and overall health. MK-7 exhibits unique properties that contribute to its effectiveness in thyroid metabolism. It is an essential cofactor for activating vitamin K-dependent proteins involved in calcium metabolism and regulation.⁹ By regulating calcium homeostasis, MK-7 ensures proper thyroid gland function and hormone synthesis.

A study involving postmenopausal women with subclinical hypothyroidism demonstrated that vitamin K2 supplementation improved thyroid function markers and positively influenced lipid profile parameters.¹⁰ These findings suggest the potential of MK-7 to support thyroid health and metabolic balance.

Guggulsterone E-Z

Guggulsterone, derived from the resin of the Commiphora mukul tree, has been traditionally used in Ayurvedic medicine to support thyroid function and metabolism.¹¹

Guggulsterone has been shown to support the activity of enzymes involved in thyroid hormone metabolism, leading to increased production of triiodothyronine (T3).¹² It also exhibits antioxidant, further supporting thyroid health.

A study investigating the effects of guggulsterone in an animal model demonstrated its ability to promote thermogenesis in brown adipose tissue, energy expenditure, and metabolic rate.¹³

Hydroxytyrosol Acetate

Hydroxytyrosol, a phenolic compound found in olive oil, exhibits antioxidant properties, making it beneficial for thyroid health and supporting its proper function.^14,15 Hydroxytyrosol Acetate acts as a free radical scavenger.¹⁶ Research has indicated the antioxidant and DNA-protective activities of hydroxytyrosol acetate, emphasizing its potential benefits in combating oxidative stress.¹⁷

Theobromine

Theobromine, a natural compound found in cocoa beans, offers several potential benefits for thyroid health and metabolism.¹⁸ While the data around theobromine is predominately centered around its antioxidant capacity, it has a direct influence, albeit to a lesser extent than caffeine, on brain function. This is key to people struggling with their thyroid function as ‘brain fog’ or ‘brain fatigue’ are common complaints in these people. However, as it relates directly to the thyroid function itself, theobromine has been shown to interact with thyroid hormone receptors, influencing their activity and supporting thyroid function.¹⁹ It may also enhance metabolic rate and stimulate thermogenesis.

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2. Venditti, P., & Di Meo, S. (2006). Thyroid hormone-induced oxidative stress. Cell Mol Life Sci, 63(4), 414-434.

3. Gärtner, R., & Gasnier, B. C. (2003). Selenium in the treatment of thyroid diseases. European Journal of Endocrinology, 148(1), 9-13.

4. Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., ... & Zeöld, A. (2008). Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocrine Reviews, 29(7), 898-938.

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9. Knapen, M. H., Drummen, N. E., Smit, E., Vermeer, C., & Theuwissen, E. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 24(9), 2499-2507.

10. Razzaque, M. S. (2018). Does vitamin K2 deficiency contribute to increased risk of cardiovascular disease in dialysis patients? Medical Hypotheses, 110, 32-34.

11. Potdar, D., Hirwani, R., & Dhulap, S. (2014). Phyto-chemical and pharmacological applications of Commiphora species. Asian Pacific Journal of Tropical Medicine, 4(12), 952-960.

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13. Seoane-Collazo, P., Fernø, J., Gonzalez, F., Diéguez, C., & Leis, R. (2015). Hypothalamic-autonomic control of energy homeostasis. Endocrine, 50(2), 276-291.

14. Corona, G., Spencer, J. P., Dessì, M. A., & Extra, J. M. (2009). Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health. In Natural Products (pp. 1-24). Springer.

15. Bulotta, S., Celano, M., Lepore, S. M., Montalcini, T., Pujia, A., & Russo, D. (2011). Beneficial Effects of Olive Oil Polyphenols on the Impaired Endothelial Function and Elevated Blood Pressure Induced by Acute Consumption of Tartrazine in Healthy Young Adults. International Journal of Food Sciences and Nutrition, 62(8), 806-812.

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17. Nisticò, S., Ehrlich, J., Gajowiak, A., & Niedzwiecki, A. (2018). Hydroxytyrosol: Health Benefits and Use as Functional Ingredient in Meat and Meat Products. Molecules, 23(9), 2329.

18. Cubeddu, L. X., Cubeddu, R. J., Heimowitz, T., & Hoffman, J. (1981). Comparative bronchodilating activity of theobromine and theophylline in patients with chronic obstructive lung disease. Chest, 80(6), 740-744.

19. Tseng, Y. H., & Kung, J. T. (1995). Effects of theobromine on adenosine and thyroid hormone levels in the rat. Pharmacology, 50(1), 24-31.