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ENHANCE

Healthspan & Longevity Support*

$143.00
Rated 4.4 out of 5
Based on 19 reviews
View Ingredients & Nutrition Facts
Qty
  • Promotes Longevity, Cellular Renewal & Autophagy
  • Supports Heart Health & Mitochondrial Free Radicals
  • Assists Cellular Detox & Optimizes Nrf2 Pathways
  • Supports Stamina + Endurance & Protein Synthesis
  • Maintains Lipid & Blood Sugar Regulation + Energy Production

Active Ingredients: Arginine Alpha-Ketoglutarate, Trimethylglycine, Bergamot Orange Extract, Bergamonte®, Epigallocatechin Gallate, Taxifolin, Spermidine

Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)

HOW

Take 3 capsules daily with water or as directed by your healthcare practitioner.

WHEN

Daily

DOSE

3 Capsules

  • Benefits

    • Promotes Longevity, Cellular Renewal & Autophagy
    • Supports Heart Health & Mitochondrial Free Radicals
    • Assists Cellular Detox & Optimizes Nrf2 Pathways
    • Supports Stamina + Endurance & Protein Synthesis
    • Maintains Lipid & Blood Sugar Regulation + Energy Production
  • Ingredients

    Active Ingredients: Arginine Alpha-Ketoglutarate, Trimethylglycine, Bergamot Orange Extract, Bergamonte®, Epigallocatechin Gallate, Taxifolin, Spermidine

    Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)

  • How To Use

    HOW

    Take 3 capsules daily with water or as directed by your healthcare practitioner.

    WHEN

    Daily

    DOSE

    3 Capsules

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Formulation

Alpha-Ketoglutarate

  • Found In
  • Citrus Fruits, Berries, Tomatoes, Spinach (in small amounts)
  • Source
  • Arginine Alpha-Ketoglutarate
  • Benefits
  • Blood Pressure, Energy Production
  • Science
  • 337 published articles

Citrus Bergamot

  • Found In
  • Bergamot Fruit (Citrus bergamia)
  • Source
  • Bergamonte®
  • Benefits
  • Cholesterol, Immune System, Mood, Mental Alertness
  • Science
  • 471 published articles

Trimethylglycine

  • Found In
  • Wheat, Beets, Quinoa, Seafood
  • Source
  • Betaine Anhydrous
  • Benefits
  • Immune Function, Liver Health, Athletic Performance
  • Science
  • 9,341 published articles

Epigallocatechin Gallate

  • Found In
  • Green Tea
  • Source
  • Camellia sinensis
  • Benefits
  • Antioxidant, Mood, Calming Support, Memory
  • Science
  • 7,138 published articles

Taxifolin

  • Found In
  • Onions, Milk Thistle, French Maritime Pine Bark
  • Source
  • Dihydroquercetin
  • Benefits
  • Liver Health, Detoxification, Brain Health, Immune Function
  • Science
  • 1,083 published articles

Spermidine

  • Found In
  • Wheatgerm, Soya beans, Mushrooms, Mature Cheeses
  • Source
  • Combination of 14-Butanediamine and SAMe
  • Benefits
  • Energy, Heart, Brain Health
  • Science
  • 14,420 published articles
overview

Healthspan & Longevity Support*

  • OVERVIEW

    Enhance is a cutting-edge dietary supplement formulated to support longevity and promote healthy aging. As we age, our cells undergo transformations that impact our well-being and lifespan, including diminished mitochondrial function, reduced autophagy, and decreased cellular renewal. Enhance leverages a precise blend of six key ingredients, including Arginine Alpha-Ketoglutarate (AAKG), Trimethylglycine (TMG), Bergamot Orange Extract, Epigallocatechin Gallate (EGCG), Taxifolin, and Spermidine. These ingredients have demonstrated efficacy in promoting healthspan, optimizing epigenetic aging, and supporting mitochondrial function and autophagy, thus facilitating cellular renewal. By targeting crucial aspects of cellular function such as mitochondrial health, oxidative stress, gene expression, and cellular renewal, Enhance offers a comprehensive approach to support healthy aging and optimize overall cellular well-being, contributing to graceful aging and enhanced longevity.

  • INGREDIENTS

    Arginine Alpha-Ketoglutarate


    Arginine Alpha-Ketoglutarate (AAKG) is a vital molecule in the tricarboxylic acid (TCA) cycle, a central pathway for energy production in cells, and is critical in cellular energy metabolism and functions such as DNA and protein synthesis. AAKG acts as a precursor to nitric oxide (NO), a signaling molecule involved in various cellular processes. By supporting nitric oxide production, AAKG promotes blood flow and oxygen delivery to tissues, optimizing mitochondrial function. Furthermore, AAKG exhibits potent antioxidant properties, reducing oxidative stress and preserving mitochondrial integrity. The combined effects of AAKG on nitric oxide production, blood flow, oxygen delivery, and antioxidation contribute to its ability to promote longevity.1,2


    Trimethylglycine


    Trimethylglycine (TMG), also known as betaine anhydrous, is a naturally occurring compound with diverse physiological functions. TMG acts as a methyl donor, supporting DNA and histone methylation, which play critical roles in gene expression regulation and maintaining cellular function. By modulating gene expression, TMG helps optimize cellular function and contributes to its longevity-promoting effects.3,4


    Bergamote®


    Natural polyphenols found in fruits, vegetables, and tea exhibit potential in the prevention and treatment of cancer through various mechanisms of action. These include antioxidant activity, modulation of cell signaling pathways, DNA methylation, and apoptosis. Bergamote® (bergamot orange extract), rich in polyphenols such as flavonoids and citrus bergamia polyphenols (CBPs), offers multiple mechanisms of action that promote longevity. Its potent antioxidant properties neutralize reactive oxygen species (ROS) and reduce oxidative stress. It has been shown to support cardiovascular health and support healthy cholesterol, blood sugar levels and weight loss.5,6,7 Additionally, bergamot orange extract supports endothelial function, promoting blood flow and cardiovascular health.8,9


    Epigallocatechin Gallate


    Epigallocatechin gallate (EGCG), a polyphenol found in green tea, promotes longevity through various mechanisms. EGCG scavenges free radicals, reduces oxidative stress, and protects cellular components as a potent antioxidant. Furthermore, EGCG supports autophagy, a cellular process that clears damaged proteins and organelles, promotes cellular function and support longevity.10,11


    Taxifolin


    Bioactive compounds, including polyphenols and flavonoids, possess the ability to support a healthy inflammatory response, including the NF-κB pathway and cytokine production. Taxifolin, also known as dihydroquercetin, is a flavonoid found in various plant sources that exhibits diverse mechanisms of action contributing to its longevity-promoting effects. It acts as a potent antioxidant, effectively scavenging free radicals and reducing oxidative stress, which can lead to cellular damage and aging. Additionally, taxifolin enhances mitochondrial biogenesis and supports electron transport chain activity, resulting in energy production and cellular respiration.12,13


    Spermidine


    Spermidine is a polyamine naturally present in various foods and cells. It plays a crucial role in cellular processes such as autophagy and gene expression regulation. Spermidine promotes autophagy, which removes damaged cellular components and supports cellular rejuvenation. By supporting autophagy, spermidine helps maintain cellular health. It also exhibits antioxidant properties, protecting cells from oxidative damage. Furthermore, spermidine regulates gene expression by interacting with chromatin and influencing histone modifications, contributing to cellular homeostasis and longevity.14,15

  • REFERENCES

    1. Allerton TD, Proctor DN, Stephens JM, Dugas TR, Spielmann G, Irving BA. l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients. 2018 Jul 19;10(7):921. doi: 10.3390/nu10070921. PMID: 30029482; PMCID: PMC6073798. https://doi.org/10.3390/nu10070921

    2. Boccardi V, Paolisso G, Mecocci P. Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging (Albany NY). 2016 Jan;8(1):12-5. doi: 10.18632/aging.100886. https://doi.org/10.18632/aging.100886

    3. Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. doi: 10.1155/2015/181260. https://doi.org/10.1155%2F2015%2F181260

    4. Yao HT, Li CC, Chang CH. Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats. Nutrients. 2019 Aug 10;11(8):1862. doi: 10.3390/nu11081862. https://doi.org/10.3390/nu11081862

    5. Ross Walker, Elzbieta Janda and Vincenzo Mollace. The Use of Bergamot-derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action. Cardiac Health and Polyphenols. Chp 84, Pg 1085-1103, 2014. http://dx.doi.org/10.1016/B978-0-12-398456-2.00084-0

    6. Micaela Gliozzi, Ross Walker, Elzbjeta Janda, Vincenzo Mollace. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol, LOX-1 expression and Protein Kinase B phosphorylation in patients with hyperlipidemia. International Journal of Cardiology Dec 2013, 170(2):140-5. https://doi.org/10.1016/j.ijcard.2013.08.125

    7. Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia 82 (2011) 309–316. https://doi.org/10.1016/j.fitote.2010.10.014

    8. Liu P, Huang J, Mei W, Zeng X, Wang C, Wen C, Xu J. Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression. Bioengineered. 2021 Dec;12(2):9496-9506. doi: 10.1080/21655979.2021.1996018. https://doi.org/10.1080%2F21655979.2021.1996018

    9. Saini RK, Ranjit A, Sharma K, Prasad P, Shang X, Gowda KGM, Keum YS. Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants (Basel). 2022 Jan 26;11(2):239. doi: 10.3390/antiox11020239. https://doi.org/10.3390%2Fantiox11020239

    10. Inoue, T., Saito, S., Tanaka, M., Yamakage, H., Kusakabe, T., Shimatsu, A., Ihara, M., & Satoh-Asahara, N. (2019). Pleiotropic neuroprotective effects of Taxifolin in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences, 116(20), 10031–10038. https://doi.org/10.1073/pnas.1901659116

    11. Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85. https://doi.org/10.2174/187152810793358741

    12. Emile Andriambeloson and others, Natural Dietary Polyphenolic Compounds Cause Endothelium-Dependent Vasorelaxation in Rat Thoracic Aorta, The Journal of Nutrition, Volume 128, Issue 12, December 1998, Pages 2324–2333, https://doi.org/10.1093/jn/128.12.2324

    13. Li J, Sun M, Cui X, Li C. Protective Effects of Flavonoids against Alzheimer's Disease: Pathological Hypothesis, Potential Targets, and Structure-Activity Relationship. Int J Mol Sci. 2022 Sep 2;23(17):10020. https://doi.org/10.3390%2Fijms231710020

    14. Madeo F, Zimmermann A, Maiuri MC, Kroemer G. Essential role for autophagy in life span extension. J Clin Invest. 2015 Jan;125(1):85-93. https://doi.org/10.1172%2FJCI73946

    15. Eisenberg, T., Knauer, H., Schauer, A. et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305–1314 (2009). https://doi.org/10.1038/ncb1975

Nutrition
Serving Size: 3 Capsule | Servings Per Container: 30
IngredientsAmount Per Serving
Arginine Alpha-Ketoglutarate
500 mg
Trimethylglycine (TMG) (as Betaine Anhydrous)
500 mg
Bergamont Orange Extract (citrus bergamia) (Fruit) (Bergamonte®) (38% Bergamot Polyphenolic Fraction® comprised of Neohesperidin, Naringin, Neoeriocitrin, Brutierifin and Melitidin)
250 mg
Epigallocatechin Gallate (EGCG) (from Green Tea 98% Extract)
100 mg
Taxifolin (from Dihydroquercetin)
10 mg
Spermidine10 mg

Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)

Physician Resource

Physician Resource

People Requiring

  • Anti-Aging Protocols

  • High Levels of Physical Activity

  • Mitochondrial Support

  • Cardiovascular Support